王玉梅
简介：
中国科学院物理研究所副研究员、博士生导师。
2006年于中国科学院物理研究所获理学博士学位，并于同年7月留所工作至今。
2014年至2017年于美国休斯顿大学物理系做访问研究。
主要研究方向：
电子显微学方法
电子显微学在热电材料原子尺度精细结构与物性研究中的应用
冷冻电子显微学方法在辐照敏感材料和蛋白质大分子中的应用
过去的主要工作及获得的成果：
本人自2002年起师从电子显微学专家李方华先生，一直从事电子显微学方法及其在功能材料中的应用研究。主要工作集中在以下三个方面：
电子显微学方法
电子显微学方法学方面。发展完善了电子显微学技术，如冷冻电镜与图像解卷处理的结合、高维空间结构解析方法、相位外推等，显著提升了高分辨电子显微学的分析能力，为复杂材料体系的原子尺度表征提供了新思路。
电子显微学应用
深入探索了Zintl相和half-Heusler材料的微观结构与热电性能的关联机制，揭示了空位缺陷、原子占位无序、塑性变形等对电声输运的调控作用，为高性能热电材料的设计提供了关键科学依据。研究成果发表于Nature、Nature Communications、Science Advances等顶级期刊，并受到国际同行的广泛关注和引用。
冷冻电镜平台搭建
建成了集冷冻制样、高分辨数据分析采集、高性能数据存储和分布式高性能GPU计算集群于一体的先进冷冻电镜表征平台。平台建成四年来产出多项高水平成果。自己利用此平台开展了一系列相关的研究工作，创新性地将冷冻电子显微镜和电子晶体学图像处理技术相结合解析了极其不耐电子束辐照样品ZIF-8结构。
代表性论文及专利：
1. M. Y. Li, D. P. Sun, W. Hao, H. Fu, Y. L. Zhang, Z. J. Li, B. Qin, Y. M. Wang*, S. Cui*, Human schlafen 14 cleavage of short double‐stranded RNAs underpins its antiviral activity, Adv. Sci., (2025), e01727.
2. J. X. Cheng, W. H. Xue, T. Y. Zhang, X. F. Li, Y. C. Zhu, L. Yin, Z. X. Fu, L. Z. Wu, C. Chen, P. Zhao, X. J. Ma, F. Jiang, X. D. Wang, M. Y. Li, J. Mao, Y. M. Wang*, F. Chao*, Q. Zhang*, A universal approach to high - performance thermoelectric module design for power generation, Joule, 9, (2025), 101818.
3. S. C. Duan, X. Bao, J. W. Huang, R. P. Shi, L. F. Fei, W. H. Xue, H. H. Yao, X. F. Li, J. Wang, X. J. Liu, J. Mao*, F. Cao*, Y.M.Wang*, Q. Zhang*, Spinodal decomposition promoting high thermoelectric performance in half-Heusler, Joule, 9, (2025), 101854.
4. P. F. Nan*, K. Wu, Q. Z. Li, Y. R. Liu, H. Z. Wang, Y. J. Lin, J. L. Zhu, J. Wu, F. Lin, Y. M.Wang*, B. H. Ge*, Unveiling the Healing Mechanism of Nanopores in Ice Films, Small, (2025), 2502245.
5. P. Zhao, W.H. Xue, Y. Zhang, S.Z. Zhi, X.J. Ma, J.M. Qiu, T.Y. Zhang, S. Ye, H.M. Mu, J.X. Cheng, X.D. Wang, S.H. Hou, L.J. Zhao, G.Q. Xie, F. Cao, X.J. Liu, J. Mao*, Y.H. Fu*, Y.M. Wang*, Q. Zhang*, Plasticity in single-crystalline Mg3Bi2 thermoelectric material, Nature, 631, (2024), 777-782.
6. X. Ai, W.H. Xue, L. Giebeler, N. Perez, B.H. Lei, Y. Zhang, Q.H. Zhang, K. Nielsch, Y.M. Wang*, R. He*, Interstitial Defect Modulation Promotes Thermoelectric Properties of p-Type HfNiSn, Adv. Energy Mater., 14, (2024), 2401345.
7. K. Wu, B.S. Yang, W.H. Xue, D.P. Sun*, B.S. Ge*, Y.M. Wang*, Cryo-EM combined with image deconvolution to determine ZIF-8 crystal structure, Chinese Phys. B, 33, (2024), 076802.
8. D. Sun, K.X. Zhu, L.Y. Wang, Z.X. Mu, K. Wu, L. Hua, B. Qin, X.P. Gao*, Y.M. Wang*, S. Cui*, Nucleic acid-induced NADase activation of a short Sir2-associated prokaryotic Argonaute system, Cell Rep, 43(7), (2024) 114391。
9. S.Q. Li, M. L*, Y.M. Wang*, X.M. Li*, Subtraction of liposome signals in cryo-EM structural determination of protein-liposome complexes, Chinese Phys. B 33(8), (2024), 088702.
10. W.H. Xue, J. Chen, H. H. Yao, J. Mao, C. Chen,* Y. M. Wang* & Q. Zhang*, Ultralow Lattice Thermal Conductivity of Zintl-Phase CaAgSb Induced by Interface and Superlattice Scattering, Small Sci. (2024), 2400147.
11. W.H. Xue, H.H. Yao, C. Chen, Q. Zhang*, Y.M. Wang*, Preferential substitution at cationic sites in 9-4-9 Zintl phase Ca9−yEuyZn4.5+δSb9, Appl. Phys. Lett., 122, (2023), 211904.
12. W.Y. Ren, W.H. Xue, S.P. Guo, R. He, L.Z. Deng, S.W. Song, A. Sotnikov, K. Nielsch, J.v.d. Brink, G.H. Gao, S. Chen, Y.M. Han, J. Wu, C.-W. Chu, Z.M. Wang*, Y.M. Wang*& Z.F. Ren*, Vacancy-mediated anomalous phononic and electronic transport in defective half-Heusler ZrNiBi, Nat. Commun, 14, (2023), 4722.
13. Z.X. Li, W.H. Xue, S. Han, Z.H. Gao, A. Li, X.B. Zhao, Y.M. Wang*, C.G. Fu*, T.J. Zhu. Ni atomic disorder in ZrNiSn revealed by scanning transmission electron microscopy, Mater. Today Phys, 34, (2023), 101072.
14. W.H. Xue, S. Li, H.L. He, S.Z. Zhi, X.F. Li, F.X. Bai, C. Chen, J. Mao*, Y.M. Wang*& Q. Zhang*. Insight into the intrinsic microstructures of polycrystalline SnSe based compounds, Nanotechnology, 34.24, (2023): 245704.
15. S.C. Duan, W.H. Xue, H.H. Yao, X.Y. Wang, C. Wang, S. Li, Z.W. Zhang, L. Yin, X. Bao, L.H. Huang, X.D. Wang, C. Chen, J.H. Sui, Y. Chen, J. Mao, F. Cao*, Y.M. Wang* & Q. Zhang*, Achieving High Thermoelectric Performance by NaSbTe2 Alloying in GeTe for Simultaneous Suppression of Ge Vacancies and Band Tailoring, Adv. Energy Mater., 12, (2022), 2103385.
16. Z.W. Zhang, H.H. Yao, Q. Wang, W.H. Xue, Y.M. Wang,* L. Yin, X.Y. Wang, X.F. Li, C. Chen, J.H. Sui, X. Lin, Y. Chen, X.J. Liu, J. Mao,* G.Q. Xie,* & Q. Zhang*, Achieving High Thermoelectric Performance in Severely Distorted YbCd2Sb2, Adv. Funct. Mater., 32, (2022), 2205215.
17. J. Chen, W.H. Xue, C. Chen, H.X. Li, C.Y. Cai, Q. Zhang* & Y.M. Wang*, All-Scale Hierarchical Structure Contributing to Ultralow Thermal Conductivity of Zintl Phase CaAg0.2Zn0.4Sb, Adv. Sci., 8, (2021), 2100109.
18. X.Y. Wang, W.H. Xue, Z.W. Zhang, X.F. Li, L. Yin, C. Chen, B. Yu, J.H. Sui, F. Cao, X.J. Liu, J. Mao, Y.M. Wang*, X. Lin* & Q. Zhang*, Stabilizing the Optimal Carrier Concentration in Al/Sb-Codoped GeTe for High Thermoelectric Performance, ACS Appl. Mater. Interfaces, 13, (2021), 45717.
19. R. He, T.S. Zhu, P.J Ying, J. Chen, L. Giebeler, U. Kühn, J. Grossman*, Y.M. Wang*& K. Nielsch*, High-Pressure-Sintering-Induced Microstructural Engineering for an Ultimate Phonon Scattering of Thermoelectric Half-Heusler Compounds, Small, 17, (2021), 2102045.
20. C. Chen, X.F. Li, W.H. Xue, F.X. Bai, Y.F. Huang, H.H. Yao, S. Li, Z.W. Zhang, X.Y. Wang, J.H. Sui, X.J. Liu, F. Cao*, Y.M. Wang* & Q. Zhang*, Manipulating the intrinsic vacancies for enhanced thermoelectric performance in Eu2ZnSb2 Zintl phase, Nano Energy, 73, (2020), 104771.
21. Q. Wang, X.F. Li, C. Chen, W.H. Xue, X.D. Xie, F. Cao, J.H. Sui, Y.M. Wang*, X.J. Liu & Q. Zhang*, Enhanced Thermoelectric Properties in p-Type Double Half-Heusler Ti2-yHfyFeNiSb2-xSnx Compounds, Phys. Status Solidi A, 217, (2020), 2000096.
22. D.D. Qin, W. Shi, W.H. Xue, H. Qin, J. Cao, W. Cai, Y.M. Wang* & J. Sui*, Solubility study of Y in n-type YxCe0.15Co4Sb12 skutterudites and its effect on thermoelectric properties, Mater. Today Phys, 13, (2020), 100206.
23. P.F. Nan, Y.J. Chang, Z.W. Chen, Y.Z. Pei, Y.S. Zhang*, Y.M. Wang* & B.H. Ge*, Revealing the origin of dislocations in Pb1−xSb2x/3Se (0<x≤0.07), Nanoscale, 12, (2020), 19165.
目前的研究课题及展望：
热电材料的结构演变与物性关联机制研究
先进电子显微学，电子晶体学方法及其在功能材料中的应用
冷冻电子显微学在辐照敏感材料中的应用研究
培养研究生情况：
每年招收来自物理、材料等专业的研究生1-2名，欢迎有透射电镜背景的毕业生来读博士学位或做博士后。
其他联系方式：
wangym@iphy.ac.cn
010-82649171
电话：
010-82649171
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